Plasmodium falciparum is the most common parasitic infection of the central nervous system in humans, and over 70% of the infections occur in Africa . This parasite has a particular propensity for the brain, in that the parasitized erythrocytes adhere to the endothelium of the brain causing neurological impairment. In severe falciparum malaria, the blood brain barrier is impaired. Evidence of brain damage comes from clinical, neuroimaging and biochemical studies. The neurological manifestations include seizures and coma, of which cerebral malaria (coma) is the most severe manifestation. The causes of the seizures and coma are not clear, but ischaemia is not a significant mechanism. Although most people appear to survive cerebral malaria without neurological deficits, up to a quarter of children have neurocognitive impairment.
This symposium aims to bring together basic scientists, psychologists and clinical scientists to discuss one of the most common CNS infections in Africa. In particular it will provide a broad background to the pathogenesis and consequences of severe malaria, highlighting the areas for further research.
Introduction
Charles Newton, Kenya
Proteomics of malaria
Evelyn Gitau, Kenya
Pathology of severe malaria
Steven Kamiza, Malawi
Neurological Complications
Richard Idro, Uganda
Neuro-cognitive consequences
Mike Kihara, Kenya